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AIM:To study the difference of microvessel density(MVD)between malignant and benign hepatic lesions and studythe relationship between MVD and dynamic enhancedmagnetic resonance imaging(MRI)for evaluation ofmicrovessels within malignant and benign hepatic lesions.METHODS:A total of 265 specimens of hepatocellularcarcinoma(HCC),122 cirrhosis tissues and 22 hepatic benignlesions were enrolled for MVD by immunohistochemistryon tissue microarray,of which 49 underwent MRIexamination before surgery,then contrast-to-noise ratios(CNR)and enhancement index(EI)in all the phases werecalculated.Pearson correlation was performed for correlationanalysis between CNR,EI and MVD.RESULTS:MVD of HCC was 22.7±15.8(mean±SD),whichwas obviously higher than that of cirrhosis tissue(8.3±7.6,P<0.01),but was not statistically different from that of benignlesions(31.3±22.7,P>0.05).Among HCC,MVD of gradesⅠ-Ⅱ was 29.9±18.6,which was much higher than those ofgrade Ⅲ(22.2±18.2,P<0.01)and gradeⅣ(22.9±19.0,P<0.01).MVD of HCC(P=0.018)and of benign lesions(P=0.014)were both correlative with CNR in arterial phase.CONCLUSION:Neoangiogenesis is an important featurefor malignant tumor,and MVD may act as a biologicalmarker in differentiating malignant from benign hepaticlesions.Dynamic enhanced MRI,especially image in arterialphase,may act as an MVD evaluation criterion for malignantand benign hepatic lesions.
AIM: To study the difference of microvessel density (MVD) between malignant and benign hepatic lesions and study the relationship between MVD and dynamic enhanced magnetic resonance imaging (MRI) for evaluation of microvessels within malignant and benign hepatic lesions. METHODS: A total of 265 specimens of hepatocellular carcinoma (HCC) 122 cirrhosis tissues and 22 hepatic benignles were enrolled for MVD by immunohistochemistry on tissue microarray, of which 49 underwent MRI examination before surgery, then contrast-to-noise ratios (CNR) and enhancement index (EI) in all the phases werecalculated. The Pearson correlation was performed for correlational analysis between CNR, EI and MVD. RESULTS: MVD of HCC was 22.7 ± 15.8 (mean ± SD), which was obviously higher than that of cirrhosis tissue (8.3 ± 7.6, P <0.01) different from that of benignlesions (31.3 ± 22.7, P> 0.05) .Among HCC, MVD of gradesⅠ-Ⅱ was 29.9 ± 18.6, which was much higher than those of grade Ⅲ (22.2 ± 18.2, P <0.01) 19. 0, P <0.01) .MVD of HCC (P = 0.018) and of benign lesions (P = 0.014) were both correlative with CNR in arterial phase. CONCLUSION: Neoangiogenesis is an important featurefor malignant tumor, and MVD may act as a biological marker in differentiating malignant from benign hepations. Dynamic enhanced MRI, particularly image in arterialphase, may act as an MVD evaluation criterion for malignant and benign hepatic lesions.