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曾发现在几内亚比绍和塞内加尔等地接种高效价(pfu>10~(4.7))Edmonston-Zagreb(EZ)麻疹疫苗后的女性儿童死亡率高于接种常规麻疹疫苗的2倍,为此本文作者对接种高效价EZ麻疹疫苗对T淋巴细胞亚群长期作用进行研究。第一组儿童接种中等效价(pfu=10~(4.6))EZ麻疹疫苗,第二组儿童接种高效价(pfu=10~(5.1～5.3))EZ麻疹疫苗,对照组儿童接种标准效价(pfu=10~(3.7))的Schwarz麻疹疫苗。被试儿童进行为期5～6年的随访,收集其指血样品,检测血液学变化情况。
It has been found that the female child mortality rate after inoculation of a high titer (pfu> 10 ~ (4.7)) Edmonston-Zagreb (EZ) measles vaccine in Guinea-Bissau and Senegal was twice as high as that of the regular measles vaccine Long-term effects of vaccination with high titer EZ measles vaccine on T lymphocyte subsets were studied. The first group of children were vaccinated with EZ measles vaccine at a median (pfu = 10 ~ (4.6)) and the second group at high titer (pfu = 10 ~ (5.1 ~ 5.3) (pfu = 10 ~ (3.7)) of the Schwarz measles vaccine. The children were followed up for 5 to 6 years to collect their blood samples, to detect changes in hematology.