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选择ＨＦＲＳ姬鼠型疫区盘锦大洼县、家鼠型疫区葫芦岛市，每个疫区选一试区与对照区，于每一试区分别接种ＨＦＲＳ长爪沙鼠肾细胞（Ⅰ型）和地鼠肾细胞（Ⅱ型）灭活疫苗各５０００人份。经过一个流行周年观察，显示两种疫苗安全，近期效果明显。沙鼠苗的中强反应率为２．１３％（５１／３５６），荧光抗体阳转率免前为６．２％（隐性感染），３针基础免疫后为１００％，一年后为５４．７６％，加强针后为１００％；抗体ＧＭＴ滴度分别为：３１．７、７９８、１６、５５７；中和抗体４次阳转率分别为０，７０．３７％、０、７３．３３％，抗体ＧＭＴ滴度分别为０、１０．７、０、１４．６。地鼠苗的中强反应率为３．９７％（５１／１２８４），荧光抗体４次阳转率分别为９．８８％（隐性感染）、１００％、３６．３６％、１００％；抗体ＧＭＴ滴度分别为３３．６、２３２、２５、３８７；中和抗体４次阳转率分别为０、５０％、１７．６５％、１００％，抗体ＧＭＴ滴度分别为０、９．３、２０、１５。但疫苗免疫针次、抗体持续时间、疫苗的远期流行病学效果等，有待进一步研究。
Select HFRS Apodemus epidemic Panjin Dawa County, Huludao City, home of the epidemic area, each endemic area to choose a trial area and control area, were vaccinated in each of the HFRS mouse Mongolian gerbils kidney cells (type Ⅰ ) And hamster kidney cells (type II) inactivated vaccine each 5,000 people. After a popular anniversary observation, both vaccines were safe and the immediate effect was evident. The strong response rate of gerbils was 2.13% (51/356), the positive rate of fluorescent antibody was 6.2% (latent infection), 100% after 3-needle basic immunization, and one year later 54.76%, 100% after strengthening the needle; antibody GMT titers were: 31.7,798,16,557; neutralizing antibody 4 times the positive conversion rates were 0,70.37%, 0,73. 33%, antibody GMT titers were 0,10.7,0,14.6. The moderate to strong response rate of the hamster seedlings was 3.97% (51/1284), and the positive rates of four times of fluorescent antibody were 9.88% (latent infection), 100%, 36.36% and 100% GMT titers were 33.6,232,25,387 respectively. The neutralization rate of neutralizing antibody was 0,50%, 17.65%, 100% respectively. The GMT titers of antibodies were 0, 9.3, 20,15. However, the number of vaccine needles, the duration of antibody, the long-term epidemiological effect of the vaccine and the like remain to be further studied.