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目的观察慢性淤胆型肝炎（ＣＣＨ）高压氧（ＨＢＯ）治疗前后肝组织超微结构的变化。方法用纯氧单仓治疗（２．５Ｍｐａ，２ｈ／ｄ， １０ ｄ／ｃｙｃ，６ ｃｙｃ）１０例 ＣＣＨ。治疗前后肝穿，透射电镜观察。结果 ９例肝组织汇管区淋巴细胞浸润和肝细胞淤胆减轻；８例肝细胞线粒体肿胀和ｋｕｐｆｆｅｒ细胞增生减轻；７例肝组织毛细胆管淤胆减轻和溶酶体数量减少；６例肝组织内毛细血管增生明显（Ｐ＜０．０５）；３例肝细胞内内质同增生减轻；２例肝细胞内高尔基体扩张、贮脂细胞增生、间质纤维增生减轻（Ｐ＞０．０５）。结论ＨＢＯ治疗ＣＣＨ，可有效地减轻肝细胞和毛细胆管淤胆及肝组织超微结构的损伤。
Objective To observe the ultrastructural changes of liver tissue before and after treatment of chronic cholestatic hepatitis (CCH) hyperbaric oxygen (HBO). Methods 10 cases of CCH were treated with pure oxygen (2.5Mpa, 2h / d, 10d / cyc, 6 cyc). Liver wear before and after treatment, transmission electron microscopy. Results The lymphocyte infiltration and hepatic cholestasis were alleviated in 9 cases of hepatic tissue. The swelling of mitochondria and the proliferation of kupffer cells in 8 cases were alleviated. The cholestasis and the amount of lysosome in 7 cases of liver tissue were reduced. Capillary proliferation (P <0.05); 3 cases of liver cells with reduced endometrial hyperplasia; 2 cases of hepatocellular expansion of Golgi apparatus, fat storage cell proliferation, interstitial fibrosis reduced (P> 0.05). Conclusion HBO treatment of CCH, can effectively reduce the liver cells and cholestasis of the bile duct and liver tissue ultrastructure damage.