本实验比较了人粒细胞集落刺激因子(hGCSF)单独和与氟康唑联合使用对小鼠隐球菌性脑膜炎的疗效。将剂量为300μg/kg或600μg/kg的hGCSF注入感染隐球菌小鼠腹腔,一组小鼠感染前3天,另一组感染后1天开始每日1次给药,而氟康唑(管饲法)于感染后1天开始给药,剂量为每日3mg/kg或5mg/kg,选择此低于最适剂量以观察hGCSF和氟 This experiment compared the efficacy of human granulocyte colony-stimulating factor (hGCSF) alone and in combination with fluconazole on cryptococcal meningitis in mice. HGCSF at a dose of 300 μg / kg or 600 μg / kg was injected intraperitoneally into the abdominal cavity of Cryptococcus neoformans mice. One group of mice were infected 3 days before infection and the other group was given once daily once a day after infection. Fluconazole Gavage) is administered 1 day after infection at a dose of 3 mg / kg or 5 mg / kg daily, and this is selected to be below the optimal dose to observe hGCSF and fluoride