自从 H_2受体拮抗剂问世以来,卓-艾氏综合征(ZES)的外科治疗在很大程度上有了变化。一些作者认为,剖腹探查术只适用于药物治疗无效者、或术前检查已证实肿瘤者。然而,新近许多报告指出,不仅十二指肠壁的孤立性胃泌素瘤,而且胰外、肠外的这种肿瘤,手术切除后都可获得很好的预后。不过,其手术大多数都同时附加全胃切除术。本文作者报告了5例胰外胃泌素瘤并(或)局部淋巴结转移,采用肿瘤及转移灶单纯摘除术,取得了良好的效果。本组男2例、女3例。年龄16～38岁,平均29.4岁。包括十二指肠溃疡3例;近端空肠溃疡并穿孔1 Since the advent of H2 receptor antagonists, the surgical treatment of Zel-Eller Syndrome (ZES) has largely changed. Some authors believe that the exploratory laparotomy is only applicable to those who have failed drug treatment or those whose preoperative examination has confirmed the tumor. However, many recent reports have pointed out that not only solitary gastrin tumors of the duodenal wall but also extrapancreatic and extra-intestinal tumors have good prognosis after surgical resection. However, most of the surgeries are accompanied by total gastrectomy. The authors reported 5 cases of pancreatic gastrinoma and/or local lymph node metastasis. The simple removal of tumors and metastases achieved good results. This group of 2 males and 3 females. Ages 16 to 38, average 29.4 years old. Includes 3 cases of duodenal ulcer; proximal jejunal ulcer and perforation 1