本文用电镜观察了两例已有视神经转移的视网膜母细胞瘤,对较晚期的视网膜母细胞瘤,光镜下菊形团已很少见,结构简单。但用电镜观察到丰富多采的复杂形态。我们研究肿瘤细胞内各种细胞器的微细变化,还探讨了细胞间的关系。并对某些组织特点进行了分析,通过对视网膜超微结构的探讨发现就是恶性度很大的肿瘤,也可能有分化迹象。 In this paper, two cases of retinoblastoma with optic nerve metastasis were observed by electron microscopy. For the later stage of retinoblastoma, the chrysanthemum has been rare under light microscope and its structure is simple. However, electron microscopy was used to observe the rich and varied complex patterns. We studied the subtle changes in various organelles in tumor cells and also explored the relationship between the cells. And some of the characteristics of the organization were analyzed, through the discussion of the ultrastructure of the retina found to be a very malignant tumor, may also have signs of differentiation.