论文部分内容阅读
目的探讨病毒性肝炎患者血清甲状腺素(T4)、铜蓝蛋白(CP)、丙氨酸氨基转移酶(ALT)和凝血酶原时间(PT)水平变化与肝功能损害程度的相关性及其临床意义。方法将所有病例分成慢性肝炎组、重型肝炎组和肝硬化组,分别采用化学发光法、散射免疫比浊法、连续监测法和凝固法分别检测T4、CP、ALT和PT。结果各病例组ALT、PT和T4与正常对照组比较,差异均具有统计学意义(P<0.05);肝硬化组ALT明显低于其他2个病例组(P<0.01);各病例组PT之间差异均具有统计学意义(P<0.05);慢性肝炎组T4高于其他病例组(P<0.05);重型肝炎组CP低于正常对照组及其他病例组(P<0.05),但慢性肝炎组和肝硬化组CP与正常对照组之间差异无统计学意义(P>0.05)。结论联合检测T4、CP、ALT和PT对病毒性肝炎的早期和鉴别诊断、病情判断以及疗效和预后评估有重要参考价值。
Objective To investigate the correlation between serum thyroxine (T4), ceruloplasmin (CP), alanine aminotransferase (ALT) and prothrombin time (PT) in patients with viral hepatitis and the degree of liver dysfunction and its clinical significance significance. Methods All patients were divided into chronic hepatitis group, severe hepatitis group and cirrhosis group. The levels of T4, CP, ALT and PT were detected by chemiluminescence, nephelometry, continuous monitoring and coagulation respectively. Results The ALT, PT and T4 in each case group were significantly different from those in normal control group (P <0.05). The ALT in cirrhosis group was significantly lower than that in the other two cases (P <0.01) (P <0.05); T4 in chronic hepatitis group was higher than other cases (P <0.05); CP in severe hepatitis group was lower than that in normal control group and other cases (P <0.05), but chronic hepatitis There was no significant difference between CP group and cirrhosis group and normal control group (P> 0.05). Conclusions The combined detection of T4, CP, ALT and PT has important reference value for the early and differential diagnosis of viral hepatitis, judgment of the disease, curative effect and prognosis evaluation.