自然杀伤细胞 (ＮａｔｕｒａｌＫｉｌｌｅｒＣｅｌｌ,ＮＫ细胞 )做为体内重要的淋巴细胞亚群 ,通过释放细胞因子参与体内免疫调节 ,在对病毒、肿瘤等免疫防御机制中起着重要作用。有研究表明 ,慢性肾衰竭患者ＮＫ细胞活性下降 ,但其下降机制及影响因素有哪些 ,报道并不多。本文 Natural killer cells (Natural killer cells, NK cells) as the body’s important lymphocyte subsets, through the release of cytokines involved in immune regulation in vivo, play an important role in the immune defense mechanisms such as viruses, tumors. Studies have shown that NK cell activity in patients with chronic renal failure decreased, but the mechanism of its decline and what are the influencing factors, not many reports. This article