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血管紧张素转化酶(ACE)是一种主要存在于肺毛细血管内皮细胞腔面的双肽羧肽酶,其作用是将血管紧张素Ⅰ转化成血管紧张素Ⅱ,并灭活缓激肽。在结节病、Gaucher 病、麻疯、矽肺和石棉肺、甲亢、糖尿病视网膜病变、急性肝炎和肝硬化患者,ACE 活性增高。作者对经腹腔镜和活检诊断的各类肝病患者测定了 ACE 活性,以期用血清AEC 活性的测定来作为某些肝脏病理变化的鉴别诊断指标。选定60名肝功能试验正常的非乙型肝炎病毒携带者作为对照。受试者包括35例慢性持续性肝炎、31例慢性活动性肝炎、57例肝硬化、32例脂肪肝、14例急性肝炎、以及12例梗阻性黄疸,从中剔除了患有已知能影响 ACE 活性之疾病的病例,按Lieberman 改良法测定 ACE 活性。结果对照组的平均 ACE 活性(±标准差),男
Angiotensin-converting enzyme (ACE) is a dipeptidyl carboxypeptidase mainly present in the luminal surface of pulmonary capillary endothelial cells. Its function is to convert angiotensin I to angiotensin II and inactivate bradykinin. ACE activity is increased in sarcoidosis, Gaucher’s disease, leprosy, silicosis and asbestosis, hyperthyroidism, diabetic retinopathy, acute hepatitis and cirrhosis. The authors measured ACE activity in various types of liver disease diagnosed by laparoscopy and biopsy in order to determine serum AEC activity as a differential diagnosis for some liver pathological changes. Sixty non-hepatitis B virus carriers with normal liver function tests were selected as controls. Participants included 35 patients with chronic persistent hepatitis, 31 patients with chronic active hepatitis, 57 patients with cirrhosis, 32 patients with fatty liver, 14 patients with acute hepatitis, and 12 patients with obstructive jaundice, from which patients with known ACE activity Of the disease cases, according to Lieberman modified ACE activity assay. Results Control group average ACE activity (± SD), male