糖尿病性神经病变是糖尿病的常见慢性并发症之一,可引起神经系统结构和功能的改变。糖尿病性神经病变的机理复杂而又不甚明了。近年来发现糖尿病性神经病变与血管、代谢、神经营养因子、自身免疫、炎症反应、氧自由基、损伤和遗传等因素相关。本文就近年来糖尿病性神经病变机理的研究及进展作一综述。 Diabetic neuropathy is one of the common chronic complications of diabetes and can cause changes in the structure and function of the nervous system. The mechanism of diabetic neuropathy is complex and not clear. In recent years, diabetic neuropathy has been found to be associated with factors such as blood vessels, metabolism, neurotrophic factors, autoimmunity, inflammatory reactions, oxygen free radicals, damage and heredity. This article reviews the recent progress in the pathogenesis of diabetic neuropathy.