论文部分内容阅读
目的探讨表观弥散系数(ADC)定量测量在评价足月新生儿缺氧缺血性脑损伤(HIE)中的价值。方法对31例临床诊断为HIE的足月新生儿(按临床诊断标准轻度组10例,中度组13例,重度组8例),进行常规MRI和DWI检查(b=1000s/mm2),同时选择6例正常足月新生儿做对照研究。测量各感兴趣区平均ADC值,并进行组间比较。结果中度组内囊后肢(PLIC)和放射冠ADC值均较对照组下降(P=0.003和P=0.001),重度组PLIC、放射冠、丘脑、豆状核和顶叶白质ADC值均较对照组下降(P值均<0.05),重度组PLIC的ADC值较中度组下降(P<0.001)。其中PLIC的ADC值下降与临床分度相符合程度高。结论ADC值定量测量可为早期诊断HIE提供客观依据,PLIC的ADC值定量测量在预后转归评价方面可能具有重要的价值。
Objective To investigate the value of quantitative assessment of apparent diffusion coefficient (ADC) in assessing neonatal hypoxic-ischemic brain damage (HIE) in term infants. Methods Totally 31 full-term newborns with clinical diagnosis of HIE underwent routine MRI and DWI (b = 1000s / mm2) according to the clinical diagnostic criteria (10 mild cases, 13 moderate cases and 8 severe cases) At the same time, 6 normal full-term newborns were selected as control study. The average ADC value of each region of interest was measured and compared between groups. Results In the moderate group, the ADC values of the posterior limbal placenta (PLIC) and the cornea of the radiation coronata were significantly lower than those of the control group (P = 0.003 and P = 0.001). The ADC values of PLIC, corona, thalamus, The control group decreased (P <0.05). The ADC value of PLIC in severe group was lower than that in moderate group (P <0.001). Among them, the decrease of ADC value of PLIC and clinical index coincide to a high degree. Conclusion The quantitative ADC value measurement can provide an objective basis for the early diagnosis of HIE. The quantitative ADC value of PLIC may have important value in the prognosis evaluation.