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目的:观察眼针疗法治疗原发性痛经的临床疗效及对经期外周血中前列腺素F2α( PGF2α)含量的影响.方法:将110例原发性痛经患者随机分为眼针组(60例)和药物组(50例).眼针组根据辨证分型选取下焦区、肝区、肾区、心区和睥区等,采用眼针治疗.药物组于月经来潮前1～2 d或有症状时开始口服布洛芬缓释胶囊300 mg,每12 h口服1次,连服3～5 d.两组均以3个月经周期为一疗程,观察两组患者外周血PGF2α含量及治疗结束后3个月、6个月的疗效和复发情况.结果:治疗结束3个月后两组疗效比较,眼针组痊愈率为55.0％( 33/60)、总有效率为95.0％( 57/60),均优于药物组的34.0％( 17/50)、82.0％ (41/50)(均P＜0.05 )；治疗结束6个月经周期后随访,眼针组复发率为9.1％( 3/33),明显低于药物组的35.3％( 6/11)；两组治疗后经期外周血PGF2α含量均明显降低(均P＜0.01).结论:眼针治疗原发性痛经疗效显著,并能降低原发性痛经患者经期外周血PGF2α水平.“,”Objective To observe the clinical curative effect of eye acupuncture therapy on primary dysmenorrhea and the effect on content of prostaglandin F2α (PGF2α) in peripheral blood of menstrual periods.Methods One hundred and ten cases of primary dysmenorrhea were randomly divided into an eye acupuncture group (60 cases) and a medication group (50 cases).In the eye acupuncture group,lower-jiao area,liver area,kidney area,heart area and spleen area,etc.were selected according to syndrome differentiation,and the eye acupuncture therapy was applied.In the medication group,300 mg Ibuprofen sustained release capsule was orally administrated 1-2 days before menstrual onset or when the symptoms appeared,once every 12 hours,for 3-5 days totally,3 menstrual periods constituting one therapeutic course.The content of PGF2αin peripheral blood,and the curative effects and recurrence 3 and 6 months after treatment were observed.Results Three months after treatment,the cured rate was 55.0％ (33/60) and the total effective rate was 95.0％ (57/60)in the eye acupuncture group,which were superior to those of 34.0％ (17/50)and 82.0％ (41/50) in the medication group (both P＜0.05).According to the following-up after 6 menstrual cycles,the recurrence rate of 9.1％ (3/33) in the acupuncture group was significantly lower than that of 35.3％ (6/11) in medication group.The contents of PGF2α in peripheral blood of menstrual periods were reduced after treatment in the two groups (both P＜0.01).Conclusion The curative effect of eye acupuncture on primary dysmenorrhea is significant,with the level of PGF2α in peripheral blood of menstrual periods reduced.