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本文从ＨＢＶ感染的角度研究肝癌家族内的遗传效应。结果表明：１，原发性肝癌（ＰＨＣ）患者一级亲属２２７人。其乙型肝炎病毒感染标记（ＨＢＶＭ）阳性率为７１．８１％，ＨＢｓＡｇ阳性率为４２．７３％，显著高于当地的自然人群（Ｐ＜０．０５）；其ＨＢＶＭ最常见模式是ＨＢｓＡｇ、抗－ＨＢｅ和抗－ＨＢｃ同时阳性，与有ＨＢＶ感染的ＰＨＣ患者ＨＢＶＭ的最常见模式相一致。２．患者同胞的ＨＢＶＭ阳性率为８２，９８％，ＨＢｓＡｇ为５１．０％，均显著高于患者双亲、子代（Ｐ＜０．０５）；且男性显著多于女性（Ｐ＜０．０５）。３．患者母亲组的ＨＢＶＭ明显高于父亲组（＋３１．４３％）。提示ＰＨＣ患者一级亲属确是一组ＨＢＶ易感人群，且肝癌家族内ＨＢＶ感染、ＰＨＣ都呈明显的、以母系亲代传递为特征的家族聚集现象；ＨＢＶ经垂直感染可导致家族性ＰＨＣ，ＰＨＣ患者同胞（尤其男性）是ＨＢＶ、ＰＨＣ最易感人群。因此，对该人群需密切关注，定期复查，警惕ＰＨＣ的发生。
This article examines the genetic effects within the family of HCC from the perspective of HBV infection. The results showed that: 1. There were 227 first-degree relatives in patients with primary liver cancer (PHC). The positive rate of hepatitis B virus infection marker (HBVM) was 71.81%, and the positive rate of HBsAg was 42.73%, which was significantly higher than the local natural population (P<0.05). The most common pattern of HBVM was HBsAg, Both anti-HBe and anti-HBc were positive, consistent with the most common pattern of HBVM in patients with HBV-infected PHC. 2. The positive rate of HBVM in the patients was 82.98%, and the HBsAg was 51.0%, both of which were significantly higher than those of the parents and offsprings (P<0.05). There were significantly more males than females (P<0.05). 3. The HBVM in the patient’s mother group was significantly higher than that in the father group (+31.43%). It is suggested that the first-degree relatives of PHC patients are indeed a group of HBV-susceptible people, and the HBV infection and PHC in the family of hepatocellular carcinoma are obvious family aggregation phenomenon characterized by maternal parental transmission; HBV vertical infection can cause familial PHC, PHC Patient siblings (especially men) are the most susceptible people with HBV and PHC. Therefore, it is necessary to pay close attention to this group of people and regularly review it to guard against the occurrence of PHC.