论文部分内容阅读
研究ＰＨＣ９２４例中家族肿瘤史对肝炎与ＰＨＣ关系的影响，结果表明：①合并ＨＢＶ感染的ＰＨＣ、乙肝组中有家族肿瘤史的患者均显著多于非乙肝组和无肝炎组（Ｐ＜０．０１～０．０５）。②乙肝组发病高峰年龄为３０～４９岁，显著高于其它两组（５０～５９，Ｐ＜０．０１）；乙肝组中有家族肿瘤史者发病高峰年龄为３０～３９岁，显著高于无家族肿瘤史者（４０～４９岁，Ｐ＜０．０１）。③肝炎后至发生临床肝癌时间乙肝组以５～９年居多，较非乙肝组１０～１４年居多提前一个年龄组（Ｐ＜０．０５），且有家族肿瘤史者比例显著高（Ｐ＜０．０５）。提示ＨＢＶ感染可促使ＰＨＣ的高发、早发，而家族肿瘤史则加速了这一进程。
To study the effect of family history of PHC in 924 cases on the relationship between hepatitis and PHC, the results showed that: 1The patients with family history of tumor in PHC and HBV-infected PHC and hepatitis B groups were significantly more than those in non-HBV and non-hepatitis groups (P<0. 01-0.05). 2 The peak age of onset was 30 to 49 years in the hepatitis B group, which was significantly higher than that in the other two groups (50 to 59, P<0.01). The peak onset of family history of the oncology in the hepatitis B group was 30 to 39 years, which was significantly higher than that of the other two groups. No family history of tumor (40 to 49 years old, P <0.01). 3 Hepatitis occurred after clinical hepatocellular carcinoma in the Hepatitis B group was 5-9 years, which was one age group earlier than the non-hepatitis B group aged 10-14 years (P<0.05), and the proportion of family history of tumor was significantly higher (P< 0.05). It is suggested that HBV infection can promote high and premature PHC, and family history of cancer accelerates this process.