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本文报告伯氏疟原虫ANKA株—斯氏按蚊—小鼠(C_(57)BL或ICR/JCL)模型。实验证明,国内常用的6个品系(C_(57)BL,ICR/JCL,615,SMMC/B,SMMC/C和昆明系)小鼠对伯氏疟原虫ANKA株输血感染都很敏感;在一定条件下,42批斯氏按蚊对伯氏疟原虫ANKA株的腺感染率为38.0±4.8%。子孢子腹腔接种后,以C_(57)BL和ICR/JCL小鼠最为敏感,且感染后小鼠平均存活20天左右。这一虫株对氯喹、甲氟喹、伯喹、乙胺嘧啶等都敏感,能正确反映常用抗疟药物的病因性预防作用和红细胞内持效作用。
This article reports the P. berghei ANKA strain - Anopheles stephensi - mouse (C_ (57) BL or ICR / JCL) model. Experiments show that 6 common strains (C_ (57) BL, ICR / JCL, 615, SMMC / B, SMMC / C and Kunming strain) are all sensitive to the blood transfusion of ANKA strain of Plasmodium berghei. Under the conditions, 42 batches of A. gifuensis infected the P. berghei ANKA strain with a gland infection rate of 38.0 ± 4.8%. After intraperitoneal inoculation of sporozoites, C_ (57) BL and ICR / JCL mice were most sensitive, and the average survival of mice after infection was about 20 days. This strain of insects is sensitive to chloroquine, mefloquine, primaquine, pyrimethamine and so on, which can correctly reflect the etiological preventive effect and erythrocyte persistence effect of commonly used antimalarial drugs.