检测9例急性乙型肝炎、14例慢性乙型肝炎(轻度)、12例慢性乙型肝炎(中重度)和17例乙型肝炎肝硬变患者的血清Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(C—Ⅳ)、透明质酸(HA)和层粘连蛋白(LN)的水平,并与200例正常人作对照.结果表明,各型乙型肝炎患者的血清PCⅢ、C一Ⅳ和LN均显著高于正常人,HA水平在慢性肝炎患者(中重度)和肝炎肝硬变组明显高于正常人,且PCⅢ、C—Ⅳ和HA随病倩的进展而升高.因此,血清PCⅢ、C一Ⅳ、HA和LN水平有助于判定肝纤维的活动程度. The serum levels of type Ⅲ procollagen (PC Ⅲ) in 9 patients with acute hepatitis B, 14 with chronic hepatitis B (mild), 12 with chronic hepatitis B (moderate and severe) and 17 with hepatitis B were detected. (C-Ⅳ), hyaluronic acid (HA) and laminin (LN) were measured and compared with 200 normal subjects.The results showed that the serum levels of PCⅢ, C-Ⅳ and LN were significantly higher than normal, HA levels in patients with chronic hepatitis (moderate and severe) and hepatitis cirrhosis group was significantly higher than normal, and PCⅢ, C-Ⅳ and HA increased with the progress of the disease Qian Therefore, serum PCⅢ, C Ⅳ, HA and LN levels help determine the degree of liver fibrosis.