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目的 :观察应用微电极导向立体定向术对不同靶点进行毁损治疗帕金森病的临床疗效。方法 :6 3例帕金森病患者 ,进行微电极导向苍白球腹后部 (PVP核 )和 (或 )丘脑 (Vim核 )毁损术 ,分析其术后临床症状的改善情况。结果 :不同症状的改善率分别为 :僵直 94.5 %、震颤 92 %、运动迟缓 86 .5 %、步态 72 .7%、平衡 6 8.8%、关状态77.9%。术后 Motor U PDRS积分“关”状态下降 6 3.4% ,“开”状态下降 5 4.3% ,左旋多巴引起的并发症基本消除。无严重及永久并发症。结论 :应用微电极导向立体定向技术 ,根据病情选择性应用 PVP核和 (或 ) Vim核毁损术能更全面、更有效地改善帕金森病患者的症状 ,从而最大限度地提高患者的生存质量。
Objective: To observe the clinical effect of microelectrode-guided stereotaxy on the treatment of Parkinson’s disease with different targets. Methods Sixty three patients with Parkinson ’s disease were treated with microelectrode - guided PVP and / or Vim nuclear ablation. The clinical symptoms were analyzed. Results: The improvement rates of different symptoms were 94.5% stiffness, 92% tremor, 86.5% delay, gait 72.7%, balance 6 8.8% and off state 77.9%. Postoperative Motor U PDRS score “off” state down 6 3.4%, “on” state down 53.3%, levodopa-induced complications were basically eliminated. No serious and permanent complications. Conclusion: The microelectrode guided stereotactic technique can selectively and effectively treat patients with Parkinson’s disease more effectively and effectively in order to maximize the patient’s quality of life.