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硝酸甘油(TNG)短期静脉给药治疗可使急性心肌梗塞患者左室功能改善,心电图缺血表现减轻。动物实验也显示,在冠状动脉闭塞后,只要不引起灌注压过低及明显的反射性心动过速,硝酸甘油可使缺血减轻,侧枝循环流量增加。晚近有研究进一步报道,以使平均动脉压降低10%的剂量静脉滴注硝酸甘油6小时,可使冠状动脉闭塞狗的侧枝血流增加,坏死范围减少约50%。本研究旨在验证急性心肌梗塞发生后48小时给予静脉硝酸甘油治疗是否能产生持久性有益作用。方法:对104例有典型急性心肌梗塞胸痛及随
Short-term intravenous administration of nitroglycerin (TNG) can improve left ventricular function in patients with acute myocardial infarction, ECG showed reduced ischemic. Animal experiments also show that after coronary occlusion, nitroglycerin can reduce ischemia and increase collateral circulation as long as it does not cause perfusion pressure is too low and significant reflex tachycardia. More recent studies have further reported, in order to make a mean arterial pressure of 10% lower doses of intravenous nitroglycerin 6 hours, coronary occlusion in dogs with increased lateral blood flow, the extent of necrosis reduced by about 50%. The aim of this study was to verify whether intravenous nitroglycerin treatment at 48 hours after acute myocardial infarction can have a lasting beneficial effect. Methods: 104 patients with typical acute myocardial infarction chest pain and with