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盐酸可乐定自70年代中期被介绍后已成为广泛用于抗高血压的药物,可乐定通过中枢机制降低血压。作为α_2兴奋剂,它使控制血压的交感神经传出减少,因为可乐定分子具有通过皮肤弥散的能力,近来对新发展的透皮制剂给药发生兴趣。这种速率控制的药物释放系统使药物供应持续一段长的时间。
Clonidine hydrochloride has been widely used as an antihypertensive drug since its introduction in the mid-1970s. Clonidine reduces blood pressure through the central nervous system. As an alpha-2 agonist, it reduces the control of blood pressure on the sympathetic outflow because of the ability of clonidine molecules to diffuse through the skin and recent interest in newly developed transdermal drug delivery. This rate-controlled drug delivery system keeps the drug supply on for a long time.