Objective To observe the effects and safety of quadruple regimens including domestically manufactured rabeprazole used as first line/initial therapy for Helicobacter pylori(H.pylori)eradication in gastritis and duodenal ulcer patients,and to investigate the effects of extended use of bismuth after the quadruple therapy on eradication Objective To observe the effects and safety of quadruple regimens including domestically manufactured rabeprazole used as first line / initial therapy for Helicobacter pylori (H. pylori) eradication in gastritis and duodenal ulcer patients, and to investigate the effects of extended use of bismuth after the quadruple therapy on eradication