幽门螺杆菌(Hp)感染引起的胃黏膜上皮细胞动力学改变在其致病机制中起关键作用。Hp感染诱导的胃黏膜上皮细胞凋亡增加,可导致细胞丢失性疾病,如萎缩性胃炎,而长期Hp感染诱导的细胞过度增殖,又可致增殖性病变如胃癌,其确切机制仍不清楚。Hp是否通过细胞周期调控异常,进而影响胃上皮细胞生长的研究尚少有报道。E2F-1在细 The changes of gastric mucosal epithelial cells caused by Helicobacter pylori (Hp) infection play a key role in the pathogenic mechanism. Hp infection induced an increase in gastric mucosal epithelial cells apoptosis can lead to cellular loss of disease, such as atrophic gastritis, and long-term Hp infection-induced cell hyperproliferation, but also cause proliferative lesions such as gastric cancer, the exact mechanism remains unclear. Hp whether through the abnormal cell cycle regulation, thereby affecting the growth of gastric epithelial cells is still rarely reported. E2F-1 is fine