【摘 要】
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Dear Editor,Over a half-century ago,Dr.Leonard Hayflick described the phenotype of a finite lifespan for human fibroblasts being passaged in in vitro cell cultu
【机 构】
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Clinical and Translational Research Center of Shanghai First Maternity Infant Hospital, Shanghai Key
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Dear Editor,Over a half-century ago,Dr.Leonard Hayflick described the phenotype of a finite lifespan for human fibroblasts being passaged in in vitro cell culture (Hayflick et al.,1961),a phenomenon today known as replicative cellular senescence.Cellular senescence has been defined as a state in which cells lose their potential to divide and are permanently arrested in either the G1,or arguably the G2 stage of the cell cycle (Mao et al.,2012).In addition to replicative cellular senescence-which is induced by large amounts of DNA damage at telomeres due to loss of the specialized T-loop structure-exogenous sublethal stresses such as ionizing radiation,genotoxic chemicals or hyper-activated oncogenes may also trigger a similar form of senescence,stress induced premature cellular senescence (SIPS).
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