论文部分内容阅读
目的:探讨围绝经期综合征患者血清细胞因子IL-1β、IL-6、TNF-α的表达情况及其临床意义。方法:2010年2月～2011年2月通过检测围绝经期综合征患者的IL-1β、IL-6、TNF-α等血清细胞因子的表达情况,了解围绝经期综合征患者的免疫功能与症状之间的相关性,为临床制订预防与治疗措施提供依据。结果:经统计学分析可见,围绝经期综合征患者治疗前血清IL-1β、IL-6、TNF-α水平与对照组比较均明显升高(P<0.05)。而在治疗后围绝经期综合征患者的血清IL-1β、IL-6、TNF-α水平均恢复至对照组水平(P>0.05),与治疗前相比较均明显下降(P<0.05)。围绝经期综合征患者治疗前改良Kupperman评分为(26.08±9.58)分,治疗后为(5.14±1.51)分;经统计学分析发现,围绝经期综合征患者治疗前后的改良Kupperman评分比较有统计学差异(t=12.67,P<0.05)。围绝经期综合征患者治疗前E2水平与IL-1β、IL-6、TNF-α呈负相关,而在治疗后FSH与IL-1β、IL-6、TNF-α呈正相关。结论:围绝经期综合征存在免疫激活作用,IL-1β、IL-6、TNF-α水平的变化可以作为病情变化的一个灵敏指标。
Objective: To investigate the expression of serum cytokines IL-1β, IL-6 and TNF-α in patients with perimenopausal syndrome and its clinical significance. Methods: From February 2010 to February 2011, we examined the serum levels of IL-1β, IL-6 and TNF-α in patients with perimenopausal syndrome to investigate the relationship between immune function and The correlation between the symptoms, provide the basis for clinical prevention and treatment measures. Results: After statistical analysis, the levels of serum IL-1β, IL-6 and TNF-α in patients with perimenopausal syndrome before treatment were significantly higher than those in the control group (P <0.05). However, the levels of IL-1β, IL-6 and TNF-α in patients with perimenopausal syndrome recovered to the level of control group after treatment (P> 0.05), and were significantly lower than those before treatment (P <0.05). Before treatment, the improved Kupperman score was (26.08 ± 9.58) points and 5.14 ± 1.51 points after treatment. According to the statistical analysis, the improved Kupperman scores of patients with perimenopausal syndrome before and after treatment were statistically significant Learning difference (t = 12.67, P <0.05). The level of E2 in patients with perimenopausal syndrome before treatment was negatively correlated with IL-1β, IL-6 and TNF-α, but there was a positive correlation between FSH and IL-1β, IL-6 and TNF-α after treatment. Conclusion: Peri-menopausal syndrome has immune activation effect, and the changes of IL-1β, IL-6 and TNF-α levels can be used as a sensitive index of disease changes.