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目的:观察替米沙坦联合辛伐他汀治疗慢性充血性心力衰竭(CHF)的疗效。方法:将132例CHF患者随机分为替米沙坦联合辛伐他汀治疗组(联合治疗组,44例)、辛伐他汀组(44例)和常规对照组(44例)3组,随访180d,观察治疗前后NYHA心功能分级,同时以超声动图检测左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)及E/A来评估治疗效果。结果:联合治疗组疗效优于辛伐他汀组和常规对照组(P<0.05)。辛伐他汀组各指标均优于常规对照组,差异有统计学意义(P<0.05)。LVEF(%)、E/A联合治疗组均优于辛伐他汀组,差异有统计学意义(P<0.05)。结论:替米沙坦联合辛伐他汀治疗CHF比单用辛伐他汀的临床疗效更好。
Objective: To observe the effect of telmisartan combined with simvastatin on chronic congestive heart failure (CHF). Methods: 132 patients with CHF were randomly divided into three groups: telmisartan combined with simvastatin (44 cases), simvastatin group (44 cases) and routine control group (44 cases), followed up for 180 days The NYHA functional class was observed before and after treatment. The left ventricular end diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF) and E / A were measured by echocardiography to evaluate the therapeutic effect. Results: The combination therapy group was better than simvastatin group and conventional control group (P <0.05). Simvastatin group indicators were better than the conventional control group, the difference was statistically significant (P <0.05). LVEF (%), E / A combined treatment group were better than simvastatin group, the difference was statistically significant (P <0.05). CONCLUSIONS: Telmisartan plus simvastatin is more effective than simvastatin alone in the treatment of CHF.