磺胺是医疗中最常用的药物,尤其在基层医疗单位中应用更广。磺胺药物的毒性作用,亦早为大家所熟知,然而由于应用中的疏忽或不慎,直到目前为止,仍有不少中毒病例发生。在磺胺药物的毒性作用中,最严重者当推急性溶血性贫血、颗粒白血球缺乏以及肾脏损害等三种,其中尤以肾脏损害为最常见。磺胺类药物引起的肾脏损害,是属于一种下肾单位肾病,其发病机制目前—般认为是由于磺胺药物本身对肾实质有直接的毒性作用(例如磺胺嘧啶),及磺胺药物形 Sulfa is the most commonly used medical drug, especially in the primary medical units more widely used. The toxic effects of sulfa drugs are also familiar as early as possible, however, due to negligence or carelessness in application, up to now, many poisoning cases still occur. In the toxic effects of sulfa drugs, the most serious when to push the acute hemolytic anemia, lack of particles of white blood cells and kidney damage in three, especially in the most common kidney damage. Sulfonamide-induced kidney damage is a form of nephrotic nephropathy and its pathogenesis is currently thought to be due to the direct toxic effects of sulfa drugs on renal parenchyma (eg, sulfadiazine) and sulfa drugs