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目的观察代谢综合征患者血浆超敏C反应蛋白、纤维蛋白原水平与胰岛素抵抗的关系,探讨炎症反应在代谢综合征患者胰岛素抵抗发生中的作用。方法选择代谢综合征患者40例和正常健康对照组30例,分别测定血浆超敏C反应蛋白、纤维蛋白原等指标;计算稳态模型胰岛素抵抗指数(HOMA-IR)。比较其水平的差异,并进行相关性分析。结果代谢综合征组的HOMA-IR较正常健康对照组明显升高(P<0.05);血浆超敏C反应蛋白、纤维蛋白原水平等也明显升高,差异具有统计学意义(P<0.05)。相关结果显示:代谢综合征患者组高敏C反应蛋白、纤维蛋白原与HOMA-IR正相关(r=0.465,0.381,P<0.05)。结论代谢综合征患者存在血浆超敏C反应蛋白水平的异常和明显的胰岛素抵抗,炎症反应可能在代谢综合征患者胰岛素抵抗的发生中发挥了重要的作用。
Objective To investigate the relationship between plasma high-sensitivity C-reactive protein and fibrinogen levels and insulin resistance in patients with metabolic syndrome and to explore the role of inflammatory response in the development of insulin resistance in patients with metabolic syndrome. Methods Forty patients with metabolic syndrome and 30 normal controls were enrolled in this study. Plasma hs-CRP and fibrinogen were measured respectively. The homeostasis model insulin resistance index (HOMA-IR) was calculated. Compare the differences of their level and make correlation analysis. Results The HOMA-IR of patients with metabolic syndrome was significantly higher than that of healthy controls (P <0.05). The levels of plasma high-sensitivity C-reactive protein and fibrinogen were also significantly increased (P <0.05) . The results showed that: patients with metabolic syndrome, high-sensitivity C-reactive protein, fibrinogen and HOMA-IR were positively correlated (r = 0.465,0.381, P <0.05). Conclusion The abnormalities of plasma high sensitivity C-reactive protein in patients with metabolic syndrome and the obvious insulin resistance may play an important role in the development of insulin resistance in patients with metabolic syndrome.