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目的:评价免疫球蛋白配合抗感染治疗对新生儿败血症的临床疗效及其对炎症因子的影响。方法:选取2014年1月—2016年12月期间收治的新生儿败血症患者92例临床资料,采用随机分组法将其分为对照组和观察组(每组46例);对照组患儿给予常规抗感染治疗,观察组患儿在对照组治疗基础上加用免疫球蛋白治疗,比较两组患者治疗的临床疗效及其对炎症因子的影响。结果:观察组患儿治疗后的临床症状复常时间和病死率,以及白细胞计数(WBC)、降钙素原(PCT)、C-反应蛋白(CRP)和血小板计数(PLT)测得值复常时间等指标均明显优于对照组(P<0.05)。结论:免疫球蛋白配合抗感染治疗对新生儿败血症的临床疗效较好,能有效改善其炎症各指标,加快了临床症状复常时间。
Objective: To evaluate the clinical effect of immunoglobulin combined with anti-infective therapy on neonatal sepsis and its effect on inflammatory cytokines. Methods: Ninety-two cases of neonatal sepsis were selected from January 2014 to December 2016. The patients were divided into control group and observation group (46 cases in each group) by random grouping method. The control group received routine Anti-infection treatment, observation group children in the control group based on the use of immunoglobulin therapy, the treatment of two groups were compared the clinical efficacy and its impact on inflammatory cytokines. Results: The clinical symptoms in children in observation group were significantly higher than those in control group (P <0.05) Often time and other indicators were significantly better than the control group (P <0.05). Conclusion: The immunoglobulin combined with anti-infective therapy has a good clinical effect on neonatal sepsis, which can effectively improve the indexes of inflammation and speed up the recovery time of clinical symptoms.