错配修复基因(Mismatch Repair genes,MMRgenes)是细胞内负责对碱基错配进行修复的基因,它们的缺陷导致癌相关基因突变不能及时有效纠正,从而使人体易感肿瘤。对MMR基因的研究最深入的是遗传性非息肉型结肠癌(HNPCC),近年来的研究也表明错配修复基因的失活与许多恶性肿瘤如子宫 Mismatch repair genes (MMRgenes) are the genes responsible for the repair of base mismatches in cells. Their defects cause the cancer-related gene mutations can not be effectively corrected in time, so that the human body is susceptible to tumors. The most profound study of MMR genes is hereditary nonpolyposis colon cancer (HNPCC). Recent studies have also shown that inactivation of mismatch repair genes is associated with many malignancies such as the uterus