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目的研究血清可溶性血管细胞黏附分子-1、P-选择素水平在急性冠状动脉综合征中的特点,探讨其对急性冠脉综合征的预测价值。方法用酶联免疫吸附法检测21例急性心肌梗死(AMI),23例不稳定型心绞痛,22例稳定型心绞痛(SAP)和20例健康对照者血清sVCAM-1、sP-选择素水平。结果ACS患者血清(UAP)sVCAM-1、sP-选择素水平均高于非ACS患者,AMI患者血清sVCAM-1浓度及sP-选择素水平较UAP患者升高(均P<0.05)。以x±2s为临界值联合检测ACS的灵敏度为73.4%,特异度为84.2%。结论ACS患者血清VCAM-1、P-选择素水平升高,提示与ACS的发生有关,是动脉粥样硬化斑块不稳定的标志,可以作为ACS的预测指标。
Objective To study the characteristics of serum soluble vascular cell adhesion molecule-1 and P-selectin levels in patients with acute coronary syndrome (ACS) and to investigate their predictive value in acute coronary syndrome. Methods Serum levels of sVCAM-1 and sP-selectin in 21 AMI patients, 23 unstable angina pectoris patients, 22 stable angina pectoris patients and 20 healthy controls were detected by enzyme-linked immunosorbent assay. Results The serum levels of sVCAM-1 and sP-selectin in patients with ACS were significantly higher than those without ACS. The serum levels of sVCAM-1 and sP-selectin in patients with AMI were higher than those in patients with UAP (all P <0.05). The sensitivity of combined detection of x ± 2s as the critical value was 73.4% and the specificity was 84.2%. Conclusions The serum level of VCAM-1 and P-selectin in patients with ACS is elevated, suggesting that it is related to the occurrence of ACS. It is a marker of atherosclerotic plaque instability and can be used as a predictor of ACS.