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目的分析肾细胞癌的CT表现与增殖细胞核抗原(PCNA)和癌基因蛋白(P53)表达的关系。方法对48例经手术病理证实的肾细胞癌,用LDP免疫组化法测定肿瘤标本中的PCNA和P53表达,并分析其与术前CT表现的关系。结果PCNA和P53的表达与肾细胞癌的组织学类型无关(P>0.05),PCNA的表达与肿瘤侵犯肾包膜、肾周脂肪间隙、肾筋膜,局部淋巴结转移,邻近器官和脉管受累有关;而P53的表达与上述征象无关。结论肾细胞癌的CT表现中,肿瘤有侵犯肾包膜、肾周脂肪间隙、肾筋膜,局部淋巴结转移及邻近器官和脉管受累征象时,提示肿瘤的恶性程度相对较高。
Objective To analyze the relationship between the CT features of renal cell carcinoma and the expression of proliferating cell nuclear antigen (PCNA) and oncogene protein (P53). Methods 48 cases of renal cell carcinoma confirmed by surgery and pathology, LDP immunohistochemical determination of PCNA and P53 in tumor specimens, and analyze the relationship with the performance of preoperative CT. Results The expression of PCNA and P53 was not associated with the histological type of renal cell carcinoma (P> 0.05). The expression of PCNA correlated with tumor invasion of renal capsule, perirenal fat gap, renal fascia, local lymph node metastasis, adjacent organs and vascular involvement Related; while the expression of P53 has nothing to do with the above signs. Conclusions In CT appearance of renal cell carcinoma, the malignancy of the tumor is relatively high when the tumor has invading the renal capsule, perirenal fat gap, renal fascia, local lymph node metastasis and the signs of the adjacent organs and vessels involved.