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目的探讨慢性肾脏病(chronic kidney disease,CKD)3~5期非透析患者25-羟维生素D[25-hydroxy vitamin D,25(OH)D]与代谢综合征(metabolic syndrome,MS)的关系。方法选取2014年1月—2015年5月CKD 3~5期非透析患者61例,收集研究对象身高、体质量、血脂、25(OH)D、血清肌酐指标,分析25(OH)D与MS的相关性。结果 61例患者25(OH)D的平均水平为(39.99±17.66)nmol/L,正常者2例(3.3%),不足者31例(50.8%),缺乏者28例(45.9%)。MS患者41例,非MS患者20例,MS发病率为67.2%。MS组与非MS组相比,体质量指数(body mass index,BMI)、高血压患者比例、糖尿病患者比例、三酰甘油水平较高,高密度脂蛋白水平、25(OH)D水平较低,差异有统计学意义(P<0.05)。与25(OH)D不缺乏组相比,缺乏组BMI、高血压患者比例、三酰甘油水平、MS比例较高,高密度脂蛋白水平较低,差异有统计学意义(P<0.05)。25(OH)D与BMI(r=–0.35,P=0.006)、三酰甘油水平(r=–0.16,P=0.039)呈负相关,与高密度脂蛋白水平呈正相关(r=0.18,P=0.026)。结论 CKD 3~5期非透析患者25(OH)D异常与MS发病率均较高,25(OH)D与MS密切相关。
Objective To investigate the relationship between 25-hydroxy vitamin D (25 (OH) D] and metabolic syndrome (MS) in non-dialysis patients with chronic kidney disease (CKD) Methods From January 2014 to May 2015, 61 cases of non-dialysis patients with stage CKD 3-5 were enrolled in this study. Body height, body weight, serum lipids, 25 (OH) D and serum creatinine were collected. The 25 (OH) D and MS Relevance. Results The average level of 25 (OH) D in 61 patients was (39.99 ± 17.66) nmol / L, in 2 normal subjects (3.3%), in 31 patients (50.8%) in the lower limit and in 28 (45.9%) in the lacking patients. 41 cases of MS patients, 20 cases of non-MS patients, the incidence of MS was 67.2%. Compared with non-MS group, the body mass index (BMI), the proportion of patients with hypertension, the proportion of patients with diabetes, the level of triglyceride, the level of high density lipoprotein and the level of 25 (OH) D in MS group were lower , The difference was statistically significant (P <0.05). Compared with 25 (OH) D-deficient group, the ratio of BMI, hypertension, triglyceride, MS, high-density lipoprotein and low-density lipoprotein were lower in the group without BMI (P <0.05). 25 (OH) D was negatively correlated with BMI (r = -0.35, P = 0.006) and triglyceride (r = -0.16, P = 0.039) and positively correlated with high density lipoprotein (r = 0.18, P = 0.026). Conclusions The 25 (OH) D abnormalities and the incidence of MS in CKD stage 3-5 non-dialysis patients are high, and 25 (OH) D is closely related to MS.