在人肝癌细胞中 P~(53)基因区的基因突变是最常见的。我们已经通过应用单股序列聚合酶法和指导多聚酶链反应产品序列的方法,研究了来自台湾的38例肝癌在 P~(53)基因区的外显示5—8的基因突变率。通过单股序列聚合酶的方法,我们发现其突变数为16(占42.1%)例,其中12例基因突变在外显示5区,3例在7区,1例在8区,在6区没有发现任何基因突变。编导多聚酶链反应产品 Mutations in the P53 gene region are most common in human hepatoma cells. We have used the single-stranded sequence polymerase method and the method of directing the polymerase chain reaction product sequence to study the mutation rate of 5-8 genes outside the P53 gene region in 38 cases of liver cancer from Taiwan. Through a single strand polymerase method, we found that the number of mutations was 16 (42.1%). Of these, 12 mutations showed 5 regions outside, 3 were in 7 regions, 1 was in 8 regions, and no mutations were found in region 6. Any gene mutation. Polymerase chain reaction products