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最近较多人发现,维生素D_3的激素型—1α,25-二羟维生素D_3[1,25(OH)_2D_3]具有免疫调节作用,如1,25(OH)_2D_3能诱导单核细胞分出,抑制T细胞产生IL_2,封闭MLC形成CTL,抑制B细胞合成并分泌Ig。1,25(OH)_2D_3的这些作用是通过1,25(OH)_2D_3与T、B细胞受体形成巨分子而发挥的。已知正常人外周血中“休止”T细胞并无1,25(OH)_2D_3 受体,只有经PHA、ConA 等刺激后才能表达。同样,只有受EBV感染的B细胞才有此受体。EBV与B细
Recently, more people have found that vitamin D_3 hormone-1α, 25-dihydroxyvitamin D_3 [1,25 (OH) _2D_3] has an immunomodulatory effect, such as 1,25 (OH) _2D_3 can induce monocyte separation, Inhibit T cells produce IL 2, block MLC to form CTL, inhibit B cell synthesis and secretion of Ig. These effects of 1,25 (OH) _2D_3 are exerted by 1,25 (OH) _2D_3 and T, B cell receptors to form macromolecules. Known normal peripheral blood “resting” T cells and no 1,25 (OH) _2D_3 receptor, only by PHA, ConA and other stimuli before expression. Similarly, this receptor is present only in EBV-infected B cells. EBV and B fine