论文部分内容阅读
Objective:To evaluate antioxidant,antimicrobial and cytotoxic activity of different parts(root, flower,leaf and stem)of Leucas aspera(L.aspera)(Labiatae).Methods:Different parts of L.aspera were extracted with 80%(v/v)methanol.The methanol extracts were subjected to antioxidant, antimicrobial and brine shrimp lethality assay.Results:All the extracts showed moderate to potent antioxidant activity,among which the root extract demonstrated the strongest antioxidant activity with the IC_(50)value of 6.552μg/mL.Methanol extract of root possessed antioxidant activity near the range of vitamin E and thus could be a potential rich source of natural antioxidant.In case of antimicrobial screening,crude extracts of root,flower,leaf and stem showed notable antibacterial activity against tested microorganisms.The root extract showed the highest mean zone of inhibition ranging from 9.0-11.0 mm against tested microorganisms,at a concentration of 100 mg/mL.In the brine shrimp lethality bioassay,it was evident that the methanol root extract did not show significant toxicity.The LC_(50)value for 12 h and 24 h observation was 2.890 mg/mL and 1.417 mg/mL,respectively.Conclusions:The present finding suggests that the methanol root extract of L.aspera could be developed as pharmaceutical products.
Objective: To evaluate antioxidant, antimicrobial and cytotoxic activity of different parts (root, flower, leaf and stem) of Leucas aspera (L. aspera) (Labiatae). Methods: Different parts of L. aspera were extracted with 80% (v / v. methanol. the methanol extracts were subjected to antioxidant, antimicrobial and brine shrimp lethality assay. Results: All the extracts of herb showed moderate to potent antioxidant activity, among which the root extract demonstrated the strongest antioxidant activity with the IC 50 value of 6.552 μg / mL. Methanol extract of root possessed antioxidant activity near the range of vitamin E and therefore could be a potential rich source of natural antioxid. In case of antimicrobial screening, crude extracts of root, flower, leaf and stem showed notable antibacterial activity against tested microorganisms. The root extract showed the highest mean zone of inhibition ranging from 9.0-11.0 mm against tested microorganisms, at a concentration of 100 mg / mL. The brine shrimp lethality bioassay, it wa s evident that the methanol root extract did not show significant toxicity. LC_ (50) value for 12 h and 24 h observation was 2.890 mg / mL and 1.417 mg / mL, respectively.Conclusions: The present finding suggests that the methanol root extract of L.aspera could be developed as pharmaceutical products.