论文部分内容阅读
实验犬在体外循环下，阻断升主动脉，使心脏缺血１２０’，同时阻断左前降支，顺行灌注冷停搏液，每２０分钟一次。实验分为：冠状静脉窦不加压组（对照组），加压２ｋＰａ组和加压４ｋＰａ组。开放升主动脉及左前降支后，辅助循环４０分钟，停机，不用正性心力药物，观察６０分钟。在同一心脏前负荷下，测量心排量（ＣＯ），与转流前ＣＯ对比，见ＣＯ恢复％在２ｋＰａ组及４ｋＰａ组均明显优于对照组（Ｐ＜０．０１）。实验结束时，左心室肌超微结构亦显示在２ｋＰａ组改变轻微，但在缺血前、后左心室肌ＡＴＰ及血清酶的改变，各组未见明显差异，本实验提示：在冠状动脉分支阻塞时，顺灌冷停搏液，同时以２ｋＰａ压力堵塞冠状静脉塞，可提高心肌保护作用，并对心肌无损伤害。
Experimental dogs under cardiopulmonary bypass, blocking the ascending aorta, so that the heart of ischemia 120 ’, while blocking the left anterior descending branch, cis-perfusion cold cardioplegia, once every 20 minutes. The experiment was divided into: coronary sinus without pressure group (control group), pressure 2kPa group and pressure 4kPa group. Open the ascending aorta and left anterior descending artery, the auxiliary cycle of 40 minutes, down, without positive cardiopulmonary drugs, observed for 60 minutes. Cardiac output (CO) was measured at the same cardiac preload, as compared with pre-flow CO, and the% CO recovery was significantly better in the 2kPa and 4kPa groups than in the control group (P <0.01). At the end of the experiment, the ultrastructure of left ventricle muscle also showed a slight change in 2kPa group, but there was no significant difference in ATP and serum enzyme in left ventricular muscle before and after ischemia. The experiment suggested that in the coronary artery branch Blocking, Shun irrigation cold cardioplegia, while 2kPa pressure plug the coronary vein plug, can improve myocardial protection, and damage to the myocardium.