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输卵管微环境含有特异性蛋白质、细胞因子、黏附因子、酶等多种物质。特异性蛋白质包括OGP和输卵管素。OGP可提高精子的存活率和活力,参与精子的获能和顶体反应,也可作为诊断子宫内膜病变的标志物。同源的输卵管素可增强精子与透明带的结合,而异源的则相反起抑制作用。细胞因子包括LIF、gp130、TNF-α、IL-6。LIF与gp130两者在胚胎的植入、蜕膜化、胎盘的形成和胎儿的发育中扮演着重要的角色。TNF-α与IL-6在防止病原体集居的同时,也促进了炎症反应,造成了输卵管局部组织损伤。黏附因子介导细胞间的黏附和信号转导,影响细胞的增殖、分化、迁移和死亡。输卵管微环境物质可作为输卵管相关疾病或病变程度检测的标志物,可作为介入治疗药物的选取及分量参考依据,有望应用于临床疾病治疗。
Tubal microenvironment contains specific proteins, cytokines, adhesion factors, enzymes and other substances. Specific proteins include OGP and tubal hormone. OGP can improve sperm survival and vitality, involved in sperm capacitation and acrosome reaction, but also as a diagnostic marker of endometrial lesions. Homologous ovalbumin can enhance sperm and zona pellucida binding, while the opposite is opposite from the inhibitory effect. Cytokines include LIF, gp130, TNF-α, IL-6. Both LIF and gp130 play an important role in embryo implantation, decidualization, placental formation, and fetal development. TNF-α and IL-6 in preventing the aggregation of pathogens, but also promoted the inflammatory response, resulting in tubal local tissue damage. Adhesion factors mediate cell adhesion and signal transduction, affecting cell proliferation, differentiation, migration and death. Tubal microenvironment material can be used as tubal disease-related disease or degree of detection of markers, can be used as interventional drug selection and component reference basis, is expected to be used in clinical disease treatment.