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目的 探讨几种非甲状腺疾病患者血清甲状腺激素水平的变化及其意义。方法 临床确诊的肾脏病患者50例、糖尿病患者71例、冠心病患者50例,以及正常健康成人30例、甲状腺机能减退患者11例。采用放射免疫分析法测定其血清甲状腺激素水平。结果 肾脏疾病、糖尿病和冠心病患者血清总T_3(TT_3)、血清总T_4(TT_4)水平均显著低于正常对照组(P值均<0.01),其TT_3均值分别为1.40nmol/L、1.46nmol/L和1.44nmol、L;TT_4均值分别为81.20nmol/L、90.32nmol/L和86.46nmol/L。血清促甲状腺激素(TSH)水平无明显变化。反三碘甲腺原氨酸(rT_3)水平肾脏疾病组无显著改变,糖尿病和冠心病组均显著升高,均值分别为1.29nmol/L(P<0.05)和1.39nmol/L(P<0.01),甲状腺机能降低组患者血清TSH水平显著升高,rT_3水平降低(P值均<0.01)。结论TSH对于非甲状腺疾病患者甲状腺功能的评价具有重要意义。
Objective To investigate the changes of serum thyroid hormone levels in several non-thyroid diseases and its significance. Methods 50 clinically diagnosed patients with kidney disease, 71 patients with diabetes, 50 patients with coronary heart disease, as well as 30 normal healthy adults, hypothyroidism in 11 patients. Serum thyroid hormone levels were measured by radioimmunoassay. Results The levels of total serum T_3 (TT_3) and total serum T_4 (TT_4) in patients with kidney disease, diabetes mellitus and coronary heart disease were significantly lower than those in the normal control group (all P <0.01). The mean TT_3 was 1.40nmol / L and 1.46nmol / L and 1.44nmol, L; TT_4 mean values were 81.20nmol / L, 90.32nmol / L and 86.46nmol / L, respectively. Serum thyrotropin (TSH) levels did not change significantly. Anti-triiodothyronine (rT_3) levels in renal disease group did not change significantly, diabetes and coronary heart disease were significantly increased, mean 1.29nmol / L (P <0.05) and 1.39nmol / L (P <0.01 ). Serum TSH levels and rT_3 levels were significantly lower in patients with hypothyroidism (P <0.01). Conclusion TSH is of great importance for the evaluation of thyroid function in patients with non-thyroid disease.