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目的观察重组乙型肝炎(乙肝)疫苗(酵母)(YDV)免疫后10年的抗体持久性及免疫记忆。方法追踪观察按照免疫程序全程免疫后10年儿童的乙肝病毒表面抗体(抗-HBs)持久性;分别对免疫后5年和10年抗-HBs阴转的儿童,加强免疫YDV 1剂,观察其免疫记忆反应。结果抗-HBs阳性率、有效阳性率、几何平均滴度逐年下降,分别由免疫后1年的92.08%、84.16%、29.21mIU/ml降至10年后的65.17%、40.45%、5.38mIU/ml;年均递减率分别为3.76%、7.82%、17.14%。抗-HBs阳性率下降速率较慢,而有效阳性率则较快,并随免疫时间的延长,各项指标的年均递减率逐年降低,推测免疫的低阳性率水平可能维持较长时间。结论YDV免疫后存在较好的免疫记忆,免疫后10年无需加强免疫。
Objective To observe the persistence and immune memory of antibody after 10 years of recombinant hepatitis B (hepatitis B) vaccine (yeast) (YDV). Methods The persistence of hepatitis B virus surface antigens (anti-HBs) was observed and monitored in children of 10 years after the whole immunization according to the immunization program. One dose of YDV was boosted in children with anti-HBs 5 and 10 years after immunization, Immune memory response. Results The positive rate, effective positive rate and geometric mean titer of anti-HBs decreased year by year from 92.08%, 84.16% and 29.21mIU / ml at one year after immunization to 65.17%, 40.45% and 5.38mIU / ml; the average annual decline rates were 3.76%, 7.82%, 17.14% respectively. The positive rate of anti-HBs decreased slowly, but the positive rate of anti-HBs was relatively fast. With the extension of immunization time, the average declining rate of each index decreased year by year. It is speculated that the low positive rate of immunization may be maintained for a long time. Conclusion There is a good immunological memory after YDV immunization, and there is no need to strengthen immunity after 10 years of immunization.