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目的对四联疗法在幽门螺杆菌阳性消化性溃疡中的应用进行分析。方法取我院2015年1月-2016年12月收治的60例幽门螺杆菌阳性消化性溃疡患者为研究对象。分成两组,30例患者实施三联疗法,设为对照组;30例患者实施四联疗法,设为实验组。对两组患者的临床疗效、幽门螺杆菌根除情况、不良反应情况进行观察和记录,并展开分析和比较。结果临床疗效以实验组总有效率较高,与对照组的数据比较显示差异性明显,有统计学意义,P<0.05;幽门螺杆菌根除率以实验组较高,与对照组的数据比较显示差异性明显,有统计学意义,P<0.05。两组患者不良反应均轻微,且发生率差异不明显,P>0.05。结论幽门螺杆菌阳性消化性溃疡患者采用四联疗法,能够使患者病情得到改善,能有效根除幽门螺杆菌,且安全性好。
Objective To analyze the application of quadruple therapy in Helicobacter pylori positive peptic ulcer. Methods Totally 60 patients with Helicobacter pylori-positive peptic ulcer admitted in our hospital from January 2015 to December 2016 were enrolled in this study. Divided into two groups, 30 patients with triple therapy, as the control group; 30 patients with quadruple therapy, as the experimental group. Clinical efficacy of two groups of patients, eradication of Helicobacter pylori, adverse reactions were observed and recorded, and analysis and comparison. Results The clinical curative effect was higher in the experimental group than in the control group, and the difference was significant compared with the control group (P <0.05). The H. pylori eradication rate was higher in the experimental group than that in the control group The difference was significant, with statistical significance, P <0.05. Adverse reactions in both groups were mild, and the difference was not significant (P> 0.05). Conclusion Helicobacter pylori positive peptic ulcer patients with quadruple therapy, patients can improve the condition, can effectively eradicate Helicobacter pylori, and good safety.