用抗癌药博莱霉素(简写BLM)治疗的主要副作用在于损伤了肺,这是由于自由基反应的缘故。此外也由于肺缺少“博莱霉素水解酶”,因而更易受毒害,因为博莱霉素水解酶可把博莱霉素分子水解成无活性形式。肺细胞受到毒害,最后就会导致威胁生命的肺纤维化。博莱霉素在起药性作用时,首先需激活至一活性中间体。活化过程中,并需有超氧阴离子自由基(O_2~+)的参加。所形成的中间体是一种 The main side effect of the treatment with the anticancer drug bleomycin (BLM) is that it damages the lungs because of the free radical reaction. In addition, because of the lack of “bleomycin hydrolase” in the lungs, it is more susceptible to poisoning because the bleomycin hydrolase can hydrolyze bleomycin molecules into an inactive form. Lung cells are poisoned and eventually lead to life-threatening pulmonary fibrosis. When bleomycin acts as a drug, it first needs to be activated to an active intermediate. During the activation process, superoxide anion radical (O 2 +) is required to participate. The formed intermediate is a