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目的：探讨中药钙离子通道拮抗剂人参皂甙单体Ｒｂ１，对白血病多药耐药细胞系（Ｋ－５６２／ＨＨＴ）的耐药逆转作用。方法：药物敏感试验采用四唑氮盐（ＭＴＴ）比色试验法。结果：Ｒｂ１在０～８０ μｍ ｏｌ／Ｌ浓度范围内对Ｋ５６２／ＨＨＴ未见明显毒性作用；２０ μｍ ｏｌ／Ｌ、４０ μｍ ｏｌ／ＬＲｂ１ 耐药逆转倍数分别为４．４、７．９ 倍。结论：Ｒｂ１ 可以逆转Ｋ５６２／ＨＨＴ的多药耐药性，并呈剂量依赖性
Objective: To investigate the drug resistance reversal effect of Ginsenoside Rb1, a traditional Chinese medicine calcium channel antagonist, on multidrug resistance cell line K-562 / HHT. Methods: Drug sensitivity test using tetrazolium salt (MTT) colorimetric assay. Results: Rb1 had no obvious toxic effect on K562 / HHT in the concentration range of 0 ~ 80 μmol / L. The reversal multiples of resistance to 20 μmol / L and 40 μmol / LRb1 were 4.4 and 7.9 times respectively. Conclusion: Rb1 can reverse the multidrug resistance of K562 / HHT in a dose-dependent manner