以S-布洛芬和L-苯丙氨酸为起始原料,经羧基的酰化、与L-苯丙氨酸的酰胺化、酸酐法酰胺化和酯的水解等4步反应合成凝胶因子D(N-[2-[4-(2-甲基丙基)苯基]-1-丙酰基]-L-苯丙氨酰基-L-苯丙氨酸),探索优化了合成条件.对所合成的产物进行了IR,~1HNMR,~(13)CNMR,ESI-MS等结构表征.在中间体的合成中,以水代替苯作溶剂;用常温代替高温进行水解反应,实现了目标产物的绿色化学合成. Using S-ibuprofen and L-phenylalanine as starting materials, the gels were synthesized by acylation of carboxyl groups, amidation with L-phenylalanine, amidation of anhydride and ester hydrolysis Factor D (N- [2- [4- (2-methylpropyl) phenyl] -1-propionyl] -L-phenylalanyl-L-phenylalanine) was explored to optimize the synthesis conditions. The synthesized products were characterized by IR, ~ 1HNMR, ~ (13) CNMR and ESI-MS. In the synthesis of intermediates, water was used instead of benzene as the solvent. The reaction was carried out at room temperature instead of high temperature to achieve the target Green chemical synthesis of the product.