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目的调查分析高血压患者基本用药情况与生命质量现状及其影响因素,为促进临床合理用药,提高患者生命质量提供参考。方法采用嵌合欧洲五维健康(EQ-5D)量表的自编问卷,纳入意识清楚、自愿参与的非继发性18周岁以上高血压患者,于2016年7月5日至2016年8月30日对成都市部分“三甲”综合医疗机构心血管内科门诊高血压患者的用药情况及生命质量状况进行调查。结果共纳入符合标准的高血压患者562例;问卷统计分析结果表明,被调查高血压患者健康效用值为0.84±0.13,健康效用值视觉模拟(EQ-VAS)评分为(73.42±13.93)分。患者用药类别以二氢吡啶类钙通道阻滞药(CCB)降压药物使用比例最高;二联用药以血管紧张素受体拮抗药(ARB)联合二氢吡啶类CCB比例最高(42.9%),三联用药以二氢吡啶类CCB+ARB+β受体阻滞药占比最高(34.5%);8.0%的二联用药患者联用了同一类药物,1.8%的二联用药患者联合使用了血管紧张素转化酶抑制药和ARB;与男性患者相比,女性患者的EQ-5D指数相对更低。结论临床上应高度关注降压药物的联合应用,尽量避免两种同类降压药物联合应用等不合理用药情况;鉴于抽样的局限,本研究相关结果尚有待大规模临床研究予以证实。
Objective To investigate and analyze the basic medication status and quality of life in hypertensive patients and its influencing factors, so as to provide reference for promoting clinical rational drug use and improving patients’ quality of life. Methods A self-compiled questionnaire based on the EQ-5D scale was included in the non-secondary hypertensive patients over 18 years of age with conscious and voluntary participation from July 5, 2016 to August 2016 On the 30th of Chengdu part of the “Top Three ” General Hospital outpatient hypertension patients with medication and quality of life conditions were investigated. Results A total of 562 hypertensive patients were included in the questionnaire. The results of questionnaire analysis showed that the health utility value of the surveyed hypertension patients was 0.84 ± 0.13, and the EQ-VAS score was (73.42 ± 13.93) points. The most commonly used antihypertensive drugs were dihydropyridine calcium channel blockers (CCBs); the highest rates of ARB and dihydropyridine CCB were the highest (42.9% The use of dihydropyridine CCB + ARB + β blockers was the highest in triple therapy (34.5%); the same drugs were used in 8.0% of patients in dual therapy and in 1.8% of patients in dual therapy ACE inhibitors and ARB; female patients have a lower EQ-5D index than men. Conclusion Clinicians should pay close attention to the combination of antihypertensive drugs, try their best to avoid the unreasonable use of two kinds of antihypertensive drugs. Due to the limitations of sampling, the results of this study have yet to be confirmed by large-scale clinical studies.