缺血再灌注损伤易导致一系列器官功能障碍,包括心肌梗死、卒中、器官移植及出血性休克。最近研究表明作为细胞死亡重要机制的细胞凋亡导致了缺血再灌注后的器官功能障碍。细胞死亡时释放的内源性危险相关模式分子可以通过吸引免疫细胞或邻近细胞上的受体来激活先天免疫系统的细胞保护应答。 Ischemia-reperfusion injury easily leads to a series of organ dysfunction, including myocardial infarction, stroke, organ transplantation and hemorrhagic shock. Recent studies show that apoptosis as an important mechanism of cell death leads to organ dysfunction after ischemia-reperfusion. Endogenous dangerously associated pattern molecules released upon cell death can activate the cytoprotective response of the innate immune system by attracting receptors on immune cells or adjacent cells.