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目的:观察吗替麦考酚酯联合强的松治疗老年难治性肾病综合征的疗效。方法:老年难治性肾病综合征患者21例,给予吗替麦考酚酯联合强的松治疗,疗程1.5年。比较治疗前、后尿蛋白定量、血肌酐、血清白蛋白、总胆固醇水平,并观察缓解率及药物不良反应。结果:治疗后尿蛋白定量、血肌酐、总胆固醇水平较治疗前降低(P<0.05),血清白蛋白水平较治疗前增加(P<0.05);完全缓解5例(23.81%),显著缓解8例(38.10%),部分缓解4例(19.05%),无效4例(19.05%),总缓解率80.95%。结论:吗替麦考酚酯联合强的松治疗老年难治性肾病综合征缓解率较高、不良反应轻。
Objective: To observe the efficacy of mycophenolate mofetil and prednisone in the treatment of senile refractory nephrotic syndrome. Methods: Twenty-one elderly patients with refractory nephrotic syndrome were given mifepristone combined with prednisone for 1.5 years. The urinary protein excretion, serum creatinine, serum albumin and total cholesterol were compared before and after treatment, and the remission rate and adverse drug reactions were observed. Results: After treatment, urinary protein, serum creatinine and total cholesterol were decreased (P <0.05) and serum albumin levels were increased (P <0.05). Complete remission was found in 5 cases (23.81%), Cases (38.10%), partial remission in 4 cases (19.05%), ineffective in 4 cases (19.05%), the total remission rate was 80.95%. Conclusion: Mycophenolate mofetil combined with prednisone treatment of senile refractory nephrotic syndrome, high remission rate, adverse reactions.