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目的探讨社区老年高血压患者焦虑情感障碍与血清炎性标记物(C-反应蛋白、白介素-1、白介素-18)之间的相关性。方法采用自行设计的一般情况问卷、焦虑自评量表(SAS)、抑郁自评量表(SDS)、社会支持评定量表(SSRS)对上海市黄埔区半淞园社区老年高血压患者1 187例进行评定分析;采用酶联免疫反应(ELISA)方法检测血清中C-反应蛋白、白介素-1、白介素-18的表达水平。结果社区老年高血压患者焦虑自评量表总分与血清C-反应蛋白的表达呈正相关(男性rho=0.21,P=0.01;女性rho=0.34,P=0.02);社区老年高血压患者焦虑自评量表总分与白介素-1、白介素-18之间相关性差异无统计学意义。结论社区老年高血压患者焦虑与血清C-反应蛋白有一定的相关性,炎症反应可能参与老年高血压焦虑的发病过程。
Objective To investigate the relationship between anxiety and affective disorder and serum inflammatory markers (C-reactive protein, interleukin-1 and interleukin-18) in community elderly hypertensive patients. Methods The general self-designed questionnaire, self-rating anxiety scale (SAS), self-rating depression scale (SDS) and social support rating scale (SSRS) Cases were evaluated. The serum levels of C-reactive protein, interleukin-1 and interleukin-18 were detected by enzyme-linked immunosorbent assay (ELISA). Results The total score of anxiety scale in elderly patients with hypertension was positively correlated with the serum level of C-reactive protein (rho = 0.21, P = 0.01 for male and rho = 0.34 for female, P = 0.02) There was no significant difference between the total score of the scale and interleukin-1, interleukin-18. Conclusion There is a certain correlation between anxiety and serum C-reactive protein in elderly patients with hypertension in community. Inflammatory reaction may be involved in the pathogenesis of hypertension-related anxiety in the elderly.