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1型糖尿病是一种慢性自身免疫性疾病 ,主要是通过 T淋巴细胞介导的免疫损伤造成胰岛细胞进行性破坏。目前认为该病的发生与遗传背景关系极为密切 ,其中 MHC- 类区域的基因型是决定 1型糖尿病易感性的最重要因素。近年来在 MHC- 类区域发现了某些基因所编码产生的蛋白参与 T淋?
Type 1 diabetes is a chronic autoimmune disease mainly caused by the destruction of islet cells by T lymphocyte-mediated immune damage. At present, the occurrence of the disease is closely related to the genetic background, and the genotype of MHC-class region is the most important factor that determines the susceptibility to type 1 diabetes. In recent years in the MHC-type region found some genes encoded by the protein involved in T lymphocytes?