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本文报道顺义县农村于1987～1990年,在不住院全面监督管理下,采用2S_3H_3R_3Z_3/4S_3H_3R_3和2H_3R_3Z_3/4H_3R_3两种全程间歇化疗方案,对303例痰涂片阳性肺结核病例的治疗效果。疗程结束两方案疗效无显著差异,分别达到99.4％及97.7％的痰菌阴转率,1年随访复发率2.4％。认为,全间歇6个月方案服药次数仅90次,病人乐于接受,给监化的村医生也减少了工作量,但须在严格的监督下进行,方能取得满意的近、远期效果。
This paper reports the treatment of 303 cases of sputum smear-positive pulmonary tuberculosis in rural areas of Shunyi from 1987 to 1990 with two full-blown intermittent chemotherapy regimens 2S_3H_3R_3Z_3 / 4S_3H_3R_3 and 2H_3R_3Z_3 / 4H_3R_3 under the condition of complete supervision and administration without hospitalization. After the end of treatment no significant difference between the two programs, respectively, 99.4% and 97.7% sputum negative conversion rate, 1-year follow-up recurrence rate of 2.4%. In the opinion of the investigators, the number of medication taken only for a total interval of 6 months was only 90 and the patients were willing to accept it. The village doctors who took care of them also reduced their workload but required strict supervision to achieve satisfactory short-term and long-term results.