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对1996~2004年甲3亚型流感病毒的HA1基因在中国南方福建省的变异特点与流行特征进行研究.对25株(其中11株基因序列来自GenBank)甲3亚型流感病毒HA1基因进行种系发生学分析.研究表明在约8个流感流行季节中,HA1基因在不断进行着点突变,期间可能发生了4次抗原性漂移.氨基酸突变的位点主要位于HA1分子抗原决定簇A~E内及附近和某些受体结合位点.其中,抗原位点B,A和受体结合位点226位的突变对于抗原漂移至关重要,但随着流感病毒的进化,抗原位点和与抗原漂移有关的关键密码子也会发生改变.因此,在亚洲南部监测甲3亚型流感病毒HA1基因阳性选择密码子的突变是很重要的.
The variation characteristics and epidemiological characteristics of HA1 gene of influenza A virus subtype 3 from 1996 to 2004 in Fujian province in southern China were studied.Among 25 strains (11 of which were from GenBank), the HA1 gene of influenza virus type A Department of genetics analysis.Studies show that in about 8 influenza epidemic season, HA1 gene in the ongoing point mutation, during which there may be four antigenic drift.Amino acid mutations in the site located in HA1 molecular epitopes A ~ E And nearby and some receptor binding sites in which the antigenic site B, A and receptor binding site mutation at 226 is essential for antigen drift, but with the evolution of influenza virus, antigenic sites and with Key codons associated with antigen drift also change, so it is important to monitor mutations in the HA1 gene positive selector codon for influenza A virus type 3 in southern Asia.